generally, the dupondius (similar in size to the As) is smaller than the sestertius, but a large dupondius might be about the same size as a small sestertius. The dupondius (after Nero) is radiate though. The primary way to tell these coins apart is color, which is not always easy.
here is a quote from Curtis Clay about this-
"Nero introduced the radiate portrait on his bronze coins, and it soon became the mark of the dupondius. Galba and Vitellius, however, spurned Nero's innovation, probably considering it vainglorious; the color of the metal became the chief mark of their dupondii, which bore laureate or bare-headed portraits just like their asses. Vespasian too spurned the radiate crown on his earliest middle bronzes, and issued yellow-metal dupondii with laureate obv. dies until early in 71, when the radiate crown was reintroduced on dupondii and again became the conventional mark of that denomination."
"Nero differentiated his dupondii and asses by REVERSE TYPE"